Publications - Claes Gustafsson group

Original articles

Molecular phylogenetics of ascomycotal adhesins - a novel family of putative cell-surface adhesive proteins in fission yeasts.
Linder T, Gustafsson CM
Fungal Genetics and Biology 2007, in press.
Pubmed
MTERF3 is a negative regulator of mammalian mtDNA transcription.
Park CB, Asin-Cayuela J, Cámara Y, Shi Y, Pellegrini M, Gaspari M, Wibom R, Hultenby K, Falkenberg M, Gustafsson CM, Larsson NG.
Cell 2007 Jul 27;130(2):273-85
Pubmed
A genome wide role for CHD remodeling factors and Nap1 in nucleosome disassembly at gene promoters.
Walfridsson J, Khorosjutina O, Matikainen P, Gustafsson CM, Ekwall K
EMBO J 2007, Jun 20;26(12):2868-79.
Pubmed
The Cdk8 module sterically blocks Mediator interactions with RNA polymerase II.
Elmlund H, Baraznenok V, Khorosjutina O, Samuelsen CO, Holmberg S, Hebert H, Gustafsson CM.
Proc Natl Acad Sci USA 2006, Oct 24;103(43):15788-93.
Pubmed
The classical srb4-138 mutant allele causes dissociation of yeast Mediator.
Linder T, Zhu X, Baraznenok V, Gustafsson CM
Biochem Biophys Res Commun 2006, Oct 27;349(3):948-53.
Pubmed
Conserved sequence box II directs transcription termination and primer formation in mitochondria
Pham XH, Farge G, Shi Y, Gaspari M, Gustafsson CM, Falkenberg M
J Biol Chem 2006, Aug 25;281(34):24647-52
Pubmed
Genome wide occupancy profile of Mediator and the Srb8-11 module reveals interactions with coding regions
Zhu X, Wiren M, Sinha I, Rasmussen, NN, Linder T, Holmberg S, Ekwall T, Gustafsson CM
Mol Cell 2006, Apr 21;22(2):169-78.
Pubmed
The structural and functional role of Med5 in the yeast Mediator tail module.
Beve J, Hu G-Z, Myers LC, Balciunas D, Werngren O, Hultenby K, Wibom R, Ronne H, Gustafsson CM
J Biol Chem. 2005 Dec 16;280(50):41366-72
Pubmed
A family of putative mitochondrial transcription termination factors shared amongst metazoans and higher plants.
Linder T, Samuelsson T, Park CB, Asin-Cayuela J, Pellegrini M, Larsson NG, Falkenberg M, Gustafsson CM
Curr Genet. 2005 Sep 29;:1-5
Pubmed
RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing.
Djupedal I, Portoso M, Spåhr H, Gustafsson CM, Allshire RC, Ekwall K.
Genes Dev 2005, Oct 1;19(19):2301-6.
Pubmed
The human mitochondrial transcription termination factor mTERF is fully active in vitro in the non-phosphorylated form.
Asin-Cayuela J, Schwendt T, Farge G, Gustafsson CM
J Biol Chem 2005, Jul 8;280(27):25499-505
Pubmed
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.
Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM.
EMBO J. 2004 Nov 24;23(23):4606-14
Pubmed
Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA.
Kanki T, Ohgaki K, Gaspari M, Gustafsson CM, Fukuoh A, Sasaki N, Hamasaki N, Kang D.
Mol Cell Biol. 2004 Nov;24(22):9823-34.
Pubmed
The Soh1/MED31 protein is an ancient component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator.
Linder T, Gustafsson CM.
J Biol Chem. 2004 Nov 19;279(47):49455-9
Pubmed
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD.
Mol Cell. 2004 Jun 4;14(5):553-7
Pubmed

Phosphorylation of the yeast Med2 Mediator Subunit by the Srb11-Srb10 cyclin-kinase.
Hallberg M, Polozkov GV, Hu GZ, Beve J, Gustafsson CM, Ronne H, Björklund S.
Proc Natl Acad Sci USA 2004, Mar 9;101(10):3370-5
Pubmed

Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro.
Spahr H, Khorosjutina O, Baraznenok V, Linder T, Samuelsen CO, Hermand D, Makela TP, Holmberg S, Gustafsson CM.
J Biol Chem 2003, Dec 19; 278(51): 51301-6
Pubmed

TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.
Samuelsen CO, Baraznenok V, Spahr H, Kieselbach T, Holmberg S, Gustafsson CM.
Proc Natl Acad Sci U S A. 2003 May;27 (11):6422-7
Pubmed

Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.
Rantanen A, Gaspari M, Falkenberg M, Gustafsson CM, Larsson NG.
Mammalian Genome 2003 14(1): 1-6
Pubmed

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.
Falkenberg M, Gaspari M, Rantanen A, Trifunovic A, Larsson NG, Gustafsson CM.
Nat Genet. 2002 Jun 17
Pubmed

Analysis of Schizosaccharomyces pombe Mediator reveals a set of essential subunits conserved between yeast and metazoan cells.
Spåhr H, Samuelsen C, Baraznenok V, Ernest I, Huylebroeck D, Remacle JE, Samuelsson T, Kieselbach T, Holmberg S, Gustafsson CM.
Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11985-90.
Pubmed

Increased in vivo apoptosis in cells lacking mitochondrial DNA gene expression.
Wang J, Silva JP, Gustafsson CM, Rustin P, Larsson NG.
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4038-43
Pubmed

Structural organisation of yeast and human Mediator complexes.
Dotson MR, Yuan CX, Roeder RG, Myers LC, Gustafsson CM, Li Y, Kornberg RD, Asturias FJ.
Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14307-14310
Pubmed

Mediator – Nucleosome interaction.
Lorch Y, Beve J, Gustafsson CM, Myers LC, Kornberg RD.
Molecular Cell 2000 Jul;6(1):197-201
Pubmed

Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair.
Feaver WJ, Huang W, Gileadi O, Myers L, Gustafsson CM, Kornberg RD, Friedberg EC.
J Biol Chem 2000 Feb 25;275(8):5941-6
Pubmed

Purification and partial characterization of the RNA polymerase II holoenzyme from Schizosaccharomyces pombe.
Spåhr H, Bève J, Larsson T, Bergström J, Karlsson KA, Gustafsson CM.
J Biol Chem, 2000 Jan 14;275(2):1351-1356
Pubmed

Conserved Structures of  Mediator and RNA Polymerase II Holoenzyme.
Asturias FJ, Jiang YW, Myers LC, Gustafsson CM, Kornberg RD.
Science 1999, Feb 12; 283:985-987
Pubmed

Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.
Otero G, Fellows J, Li Y, de Bizemont T, Dirac AM, Gustafsson CM, Erdjument-Bromage H, Tempst P, Svejstrup JQ.
Molecular Cell 1999 Jan;3(1):109-18
Pubmed

Mediator protein mutations that selectively abolish activated transcription.
Myers LC#, Gustafsson CM#, Hayashibara KC, Brown PO, Kornberg RD.
Proc Natl Acad Sci U S A 1999 Jan 5;96(1):67-72. #Equal contribution
Pubmed

Identifcation of new subunits of the mediator complex from Saccharomyces cerevisiae.
Gustafsson CM, Myers LC, Beve J, Spåhr H, Lui M, Erdjument-Bromage H, Tempst P, Kornberg RD.
J Biol Chem 1998 Nov 20;273(45):30851-30854
Pubmed

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain.
Myers LC#, Gustafsson CM#, Bushnell DA, Lui M, Erdjument-Bromage H, Tempst P, Kornberg RD.
Genes Dev 1998 Jan 1;12(1):45-54. #Equal contribution
Pubmed

Yeast RNA polymerase II transcription reconstituted with purified proteins.
Myers LC, Leuther K, Bushnell DA, Gustafsson CM, Kornberg RD.
Methods 1997 Jul;12(3):212-6
Pubmed

Review articles, book chapters etc.

DNA replication and transcription in mammalian mitochondria.
Falkenberg M, Larsson NG, Gustafsson CM.
Annu Rev Biochem. 2007;76:679-99
Pubmed
Mitochondrial transcription and its regulation in mammalian cells.
Asin-Cayuela J, Gustafsson CM.
Trends Biochem Sci. 2007 Mar;32(3):111-7.
Pubmed
The yeast Mediator complex and its regulation.
Bjorklund S, Gustafsson CM.
Trends Biochem Sci. 2005 May;30(5):240-4
Pubmed
The transcription machinery in mammalian mitochondria.
Gaspari M, Larsson NG, Gustafsson CM.
Biochim Biophys Acta. 2004 Dec 6;1659(2-3):148-52
Pubmed

The mediator complex.
Bjorklund S, Gustafsson CM.
Adv Protein Chem. 2004;67:43-65
Pubmed

Mediator of transcriptional regulation.
Gustafsson CM, Samuelsson T.
Mol Microbiol. 2001 Jul;41(1):1-8
Pubmed

Genetic analysis of proteins.
Borén J, Gustafsson CM.
in Practical Methods in Protein Biochemistry, CRC press, 2001.

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyklin dependent kinases.
Gustafsson CM, Spåhr H, Beve J, Kubista M.
Chemtracts 1999, September